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Cannabis / CBD / THC / cannabidiol / tetrahydrocannabinol

UPDATE:  After looking into the research, and noting the big fad/trend towards CBD products, and seeing enough clients of mine (who are known Poison/"Vitamin A" toxic) have some negative experiences with CBD, I decided to do some more research on it.

Changes on metabolic parameters induced by acute cannabinoid administration (CBD, THC) in a rat experimental model of nutritional vitamin A deficiency

In contrast, the intraperitoneal administration of CBD to the control animals led to a considerable increase in plasmatic RBP and hepatic retinol levels, whereas similar plasmatic levels of RBP were found after vehicle or THC administration.

This would only be an issue with chronic (long-term) use.  Does CBD's long-term known side effects look at all like common Poison/"Vitamin A" toxicity symptoms?

An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies

Here, the most commonly reported side effects were tiredness, diarrhea, and changes of appetite/weight.

Those three symptoms are quite common for Poison/"Vitamin A" issues, and are some of the first symptoms to resolve when people do the Poison/"Vitamin A" and Glyphosate Detox Program.  Coincidence?  You tell me.

It is quite possible that some of the benefits noted from CBD are because it takes Poison/"Vitamin A" out of the bloodstream and stores it in the liver.  Short-term, this helps people feel better, long-term it only delays the inevitable (kicks the can down the road).

It seems that the more toxic one is, the more likely they are to have a negative response to CBD (which makes sense, their liver is already very full).  I'm not against CBD per se...knowing what I know now, I would only use it myself on an "as-needed" basis for a specific issue.  I would not use it daily or almost "nutritionally" as some out there seem to be pushing it.

Back to the other research...and this is mostly on THC (Cannabis sativa).  I may need to do two separate posts for CBD and THC in the future.

It seems that certain components of the Cannabis plant family have protective properties against Poison/"Vitamin A" toxicity.  Yes, there is the endocannabinoid system and all that...and what if many of the benefits of these cannabinoids may come from a protective effect against Poison/"Vitamin A" toxicity?

Cannabinoids Protect Cells from Oxidative Cell Death: A Receptor-Independent Mechanism

The antioxidative property of cannabinoids was confirmed by their ability to antagonize oxidative stress and consequent cell death induced by the retinoid anhydroretinol [a form of Poison/"Vitamin A"]. Therefore, cannabinoids act as antioxidants to modulate cell survival and growth of B lymphocytes and fibroblasts.

Read the above again.  Cannabinoids prevented cell death induced by Poison/"Vitamin A".

Cannabis smoke directly breaks down beta-carotene:

Chemical and biological studies of β-carotene after exposure to Cannabis sativa smoke

Our results showed that the BC [beta-carotene, the main plant form of Poison/"Vitamin A] exposed to CSS [Cannabis sativa smoke] underwent 98.8% degradation and suffered loss of its antiradical activity.

The following paper is referencing the first study I linked above, and added some important information about Vitamin E (alpha-tocopherol).  I have a whole article discussing the protective effects of Vitamin E against Poison/"Vitamin A" toxicity, and the quote below suggests that both THC and Vitamin E are protective against the oxidative stress and cell death caused by Poison/"Vitamin A" in a similar way.  See below.

Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression

They also performed experiments with α-tocopherol, the most potent isomer of the antioxidant vitamin E and with retinod anhydroretinol, which induces oxidative cell death [form of Poison/"Vitamin A"], either in the presence or absence of THC. Their results demonstrated that similar to the effect of α-tocopherol, and unlike retinoid anhydroretinol , THC was able to protect 5/2 cells [cultured human beta lymphoblastoid cells] from oxidative stress and cell death.

In summary:

  • Cannabinoids are protective to the cells against Poison/"Vitamin A", in a similar way to Vitamin E.
  • Cannabis sativa smoke directly breaks down beta-carotene (this is a good thing).

It is quite possible, in my opinion, that many of the benefits of medical cannabis may be directly related to these effects on Poison/"Vitamin A".

Dr. Garrett Smith, the "Nutrition Detective"
Licensed Naturopathic Physician (NMD) in Arizona
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