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Autoimmunity is foundationally Poison/"Vitamin A" toxicity, with other triggers layered on top of it

(if you are seeing this, then this post is still in progress).

I'm not going to beat around the bush here, I'm going to get right to it.  This is a long post, so settle in.

To be blunt:

  • I don't care much what "modern medicine" says causes autoimmune disease.  Actually, most of the time they don't even try to say what causes it, because they have no clue.  They have no good treatments for it, except poisoning people further ("chemotherapy"), or shutting down their immune system (via pharma poisons).  This means that they DO NOT UNDERSTAND IT AT ALL.  Therefore, I don't care about their theories on it.  If they knew what it was, they would be much closer to fixing it.
  • The victim-oriented theory of a "poor dumb body attacking itself because its immune system has lost its way" is garbage.  There is a cause.  It is toxicity/poisoning, particularly that of Poison/"Vitamin A".
  • Most of the "alternative" health world's approaches involve strictly avoiding nearly anything that anyone can theorize would cause any sort of immune reaction in the body, leaving people with extremely few food options and basically turning them into shut-ins.  When people know the cause(s), then this isn't necessary.

So, I'm going to do my best here on this gigantic topic to show that autoimmunity is a POISONING, and that the SCIENCE points towards it being a POISONING.  As we are seeing in people working with me via individualized Nutritional Restoration and/or the Poison/"Vitamin A" and Glyphosate Detox Program, when the poison is removed, over time the "autoimmunity" (POISONING) goes away and the body is able to fix itself.

First, "what is autoimmunity?", to set the stage.

What is Autoimmunity?...from John Hopkins Autoimmune Disease Research Center

Definition of autoimmunity. The healthy human body is equipped with a powerful set of tools for resisting the onslaught of invading microorganisms (such as viruses, bacteria, and parasites). Unfortunately, this set of tools, known as the immune system, sometimes goes awry and attacks the body itself. These misdirected immune responses are referred to as autoimmunity, which can be demonstrated by the presence of autoantibodies or T lymphocytes reactive with host antigens.

So we have the presence of antibodies, and more specifically, autoantibodies.  This is important.

Definition of autoimmune disease. Autoimmunity is present in everyone to some extent.

One might call this an "epidemic" then!  If this were a poisoning on a worldwide scale, then we could expect to find it in varying amounts in everyone, no?

It is usually harmless and probably a universal phenomenon of vertebrate life.

"The poison is in the dose."  Small amounts of poison, less problems, equals "usually harmless".  Larger amounts of poison, more problems, equals a recognizable disease state.

Back to the Johns Hopkins article:

However, autoimmunity can be the cause of a broad spectrum of human illnesses, known as autoimmune diseases. This concept of autoimmunity as the cause of human illness is relatively new, and it was not accepted into the mainstream of medical thinking until the 1950s and 1960s.

Poison/"Vitamin A" in our environments has been steadily increasing through all these decades, as have the other poisonous agrochemicals and pharmaceuticals that block normal detoxification pathways of Poison/"Vitamin A", thus causing the buildup of toxicity.  Notice how autoimmunity was "accepted into the mainstream" in the 1950s, the same time it was recognized in mice!  For those who want to blame glyphosate for everything, this is 20+ years before glyphosate, and yet glyphosate is heavily involved in the modern autoimmune epidemic today, particularly in how it blocks the Phase 1 cytochrome systems of the liver that detoxify Poison/"Vitamin A".

Autoimmunity is showing up in domesticated and zoo animals.  We are poisoning them too. This is how the "universal phenomenon" is being observed. To show that autoimmunity is a NEW phenomenon that goes right along with the poisoning model (as opposed to the "faulty genetics" victim mentality, let us look further to the veterinary world:

Veterinary autoimmunity: autoimmune diseases in domestic animals.

The first spontaneous animal model of autoimmunity was the New Zealand black mouse, discovered in 1959. Interestingly, although several models of induced autoimmunity were demonstrated in a variety of rodents, the recognition of autoimmune disease in dogs came somewhat later.

So autoimmunity in animals has only been recognized in mice since 1959, with dogs showing it later!  Amazing coincidence that it showed up in humans and animals around the same 20-year time period, right?  Do you think that human AND animal genetics all started falling apart at the same time, or is a massive poisoning syndrome much more reasonable?  Autoimmunity is a NEW problem in medicine, not some "universal phenomenon of vertebrate life" nonsense.

Autoimmune diseases are, thus, defined when the progression from benign autoimmunity to pathogenic autoimmunity occurs.

This is a great example of how modern medicine is "disease care" and not "health care" at all.  If autoimmunity is going on, benign or pathogenic, there is a PROBLEM that needs addressing.  Waiting until outright noticeable tissue destruction starts means that the disease/poisoning has progressed much further and will be more difficult to fix.  It can be's similar to realizing something is wrong with your car and fixing it early, or waiting until your car fully breaks and then fixing it.  The latter option is always MUCH more expensive and time-consuming.  Same thing with autoimmunity...fix it early and quicker, or fix it later and take longer.

This progression is determined by both genetic influences and environmental triggers.

Environmental triggers means both acute triggers (trauma, vaccines, medications, major poisonings) and chronic triggers (slow poisonings, nutrient deficiencies, etc.).  "Nutrition" is EVERYTHING that comes into your body, good or bad.  Never forget this.

Genetic influences.  I look at this one differently.  In terms of Poison/"Vitamin A" causing the same problems in a family/genetic line, I believe that different people have different genetic weaknesses (weak links in the chain) that the poisoning will attack and destroy first.


  • My father died of metastatic prostate cancer, which as I have shown elsewhere in this blog, is linked to Poison/"Vitamin A".
  • I started getting urinary issues, likely related to developing prostate issues, in my mid-20s.  Now, after having done the Poison/"Vitamin A" and Glyphosate Detox, I do not have any urinary issues any longer.  Sadly, I figured all this out too late to help my father.
  • I did not "fix my genetics" or treat my (beware, victim mentality ahead) "dirty genes" or do anything else based on DNA testing or methylation.  I simply GOT THE POISON OUT and my "weak link in the chain" fixed itself.  That's how this works.

Hashimoto's thyroiditis and multiple sclerosis can be reproduced by immunizing the animal with an antigen analogous to the putative autoantigen of the human disease.

Hold up here.  JOHNS HOPKINS MEDICAL INSTITUTIONS just said that "immunizing", aka "vaccinating" an animal can be used to REPRODUCE AUTOIMMUNITY. Are you still getting those poisons injected into you and wondering why you're sick?  Seriously?

When direct and indirect evidence to define an autoimmune disease are not available, investigators are left with  circumstantial evidence, that is, with listing "markers" descriptive of autoimmune disease. Examples of these markers are:

  • positive family history for the same disease, or for other diseases known to be autoimmune

See "weak link in the chain" above.

  • presence in the same patient of other known autoimmune diseases

This is a systemic poisoning breaking one weak link, then a second link, then a third link, and on and on.  It is well-accepted that once one autoimmune disease is present, that more are likely to follow.  In my view, this is simply a sign that the POISONING is going deeper and deeper.

  • presence of infiltrating mononuclear cells in the affected organ or tissue
  • preferential usage of certain MHC class II allele
  • high serum levels of IgG autoantibodies
  • deposition of antigen-antibody complexes in the affected organ or tissue

Does the body do these things in cases of poisoning as well?  We will cover them.  None of the above markers have moved modern medicine any closer to finding the actual CAUSE of autoimmunity though, because they are looking everywhere EXCEPT at poisonings.

  • improvement of symptom with the use of immunosuppressive drugs (such as corticosteroids)

I'm going to take a quick aside here.  In the following, I am NOT giving advice to anyone to TAKE corticosteroids.  That said, it is stated above that corticosteroids help to reduce/alleviate the symptoms of autoimmunity.  Do corticosteroids affect Poison/"Vitamin A" in the body?  You betcha!  From the paper A relationship between vitamin A metabolism and cortisone."The administration of large doses of cortisone to normal or adrenalectomized rats on a stock or vitamin A free diet results in a rapid loss of vitamin A from their livers and the kidneys."

So large doses of cortisone rapidly depletes Poison/"Vitamin A" from the liver and kidneys, and cortisone (a corticosteroid) is one of the main classes of drugs used to manage the symptoms of autoimmune disease?  Interesting, right?

Note:  I am not recommending the use of cortisone to treat anything without it being used in the proper context.  The above is a connection furthering my point that the foundation of autoimmunity is in Poison/"Vitamin A" toxicity.  You decide to do anything with corticosteroids and their GIGANTIC list of side effects, that is on YOU.  I do not use them at all with my clients, because we fix the underlying CAUSE(S).

Common threads uniting the autoimmune diseases are the presence of an autoimmune response based on cumulative genetic risk factors, combined with an environmental contribution (infectious, chemical, physical, or other). Equally important, innovative treatments applied to one autoimmune disease may be useful in others.

We covered my theory on the genetic links.

Environmental contributions include Poison/"Vitamin A", glyphosate/Roundup (stops breakdown of Poison/"Vitamin A", allowing toxicity at much lower levels), other medications that stop breakdown of Poison/"Vitamin A" (includes antibiotics), and infectious triggers (vaccines guarantee the introduction of pathogens and known toxins).

The common thread in all autoimmune diseases, as noted by the common use of corticosteroids in autoimmunity and the effect of corticosteroids on autoimmunity symptoms, is Poison/"Vitamin A" at the foundation.

Let's do a quick reminder of a couple of things I've already connected Poison/"Vitamin A" to, in relation to autoimmunity.

Poison/"Vitamin A" has been studied for use as an adjuvant in vaccines.  Adjuvants in vaccines have caused enough autoimmunity that there is a name for it:  Autoimmune/inflammatory Syndrome Induced by Adjuvants (ASIA).  See this post for much more on this connection.

ADJUVANT SUMMARY:  Adjuvants are associated with causing autoimmunity.  Poison/"Vitamin A" has been well-studied to be used as an adjuvant.

Next, Poison/"Vitamin A" has been used as chemotherapy. To give you an idea of my stance on chemotherapy, it wasn't the cancer that killed my father, it was his 5th round of chemo that put the nails in his coffin.  Chemotherapy is poison, robbing Peter to pay Paul, hoping that the poison kills the cancer before the patient, while guaranteeing that even if the patient lives, that they are more toxic forever after that.  Here are the multiple types of retinoids (Poison/"Vitamin A") given as chemotherapy, from the very conventional pro-chemo website

It is important to note that carotenoids TURN INTO various retinoic acids in the body.  People like to mention carrot juice and cancer success stories (well, at least maybe short-term successes, much like other chemotherapies).  The massive amounts of beta-carotene and other carotenoids in carrot juice (and many other high-carotenoid juices) will eventually turn into retinoic acid...making them an indirect way of giving the first two chemotherapy agents above.  Does chemotherapy "work" long-term?  Does poisoning the body ever end up with a positive long-term outcome?  My answer is no.

For you people still in denial, saying that somehow fruit and vegetable carotenoids are "different" than the pharmaceutical retinoids mentioned above, let me poke a hole in that idea once again:

Modulation of plasma all-trans retinoic acid concentrations by the consumption of carotenoid-rich vegetables.

RESULTS AND CONCLUSION: This study shows that consumption of carrot juice containing high concentrations of the pro-vitamin A carotenoid beta-carotene results in slightly, non-significantly increased plasma ROL concentrations and strong, significantly increased (almost double, from 1.2 +/- 0.3 to 2.0 +/- 0.31 ng/mL) plasma concentrations of ATRA, whereas consumption of tomato juice and spinach powder results in no significant alteration in concentrations of plasma ROL and ATRA.

Why does carrot juice "work" short-term for cancer?  Because it significantly increases ATRA, which is a known chemotherapeutic agent.  See above list.

Chemotherapy has ALSO been associated with causing autoimmunity, here are three papers discussing this known fact:

Autoimmunity associated with immunotherapy of cancer.

However, although initially advocated as being more specific for cancer and having fewer side effects than conventional therapies, it is becoming increasingly clear that many immunotherapies can lead to immune reactions against normal tissues. Immunotoxicities resulting from treatment can range from relatively minor conditions, such as skin depigmentation, to severe toxicities against crucial organ systems, such as liver, bowel, and lung. Treatment-related toxicity has correlated with better responses in some cases, and it is probable that serious adverse events from immune-mediated reactions will increase in frequency and severity as immunotherapeutic approaches become more effective.

Cancer and autoimmunity: autoimmune and rheumatic features in patients with malignancies

Patients with malignant diseases may develop autoimmune phenomena and rheumatic diseases as a result of [...] (c) Rheumatism after chemotherapy, a clinical entity characterised by the development of musculoskeletal symptoms after combination chemotherapy for malignancy.

CONCLUSION Autoimmune and rheumatic features are not rare among patients with malignancies.

Immunotherapy of autoimmunity and cancer: the penalty for success

Ironically, effective tumour immunity requires the induction of the same responses that underlie autoimmunity, whereas autoimmunity is driven by dysregulation of the same mechanisms that are involved in host defence and immune surveillance.

CHEMOTHERAPY SUMMARY:  Chemotherapy has been shown to induce autoimmunity.  Poison/"Vitamin A" is used as chemotherapy.

Now, let's lay out the "autoimmunity as a poisoning" trail.  When we put enough things together, it becomes fairly obvious.

Autoimmune disease is associated with antibodies, specifically autoantibodies ("self" antibodies").

What are antibodies?  Antibodies are "blood proteins produced in response to and counteracting a specific antigen. Antibodies combine chemically with substances which the body recognizes as alien, such as bacteria, viruses, and foreign substances in the blood."

What are antigens?  Antigens are "a toxin or other foreign substance which induces an immune response in the body, especially the production of antibodies."

Occam's Razor is a problem-solving principle that essentially states that "simpler solutions are more likely to be correct than complex ones."  Read the definitions of antibodies and antigens above.  Notice the key presence of words like "alien", "foreign", and "toxin".  The idea that our bodies produce antibodies in relation to poisons/toxins/foreign substances is a much simpler solution than the mental gymnastics required to decide that our bodies all of a sudden completely malfunction and start attacking itself!

I want to lay out the antibody concept a bit more.

Antibodies are a reaction to foreign/alien/toxic/poisonous substances.  FULL STOP.

Therefore, if there are antibodies of any type present, it is a sign that the body is "dealing with" or "under attack" (if you prefer the war type analogies modern medicine loves so much) from foreign/alien/toxic/poisonous substances.

Here is the important concept.

Think of it like a house security alarm.
It is there for a protective reason.
You have it so it can be used/effective, YET you don't want it to triggered, because that means someone is breaking into your house!
The same is true of antibodies.
You want your body to be able to MAKE them when NECESSARY, of course!
However, the presence of antibodies means that there is something foreign/alien/toxic/poisonous present that your body is actively "dealing with"!
Therefore, we can then logically come to the conclusion that THINGS THAT INCREASE ANTIBODIES OF ANY TYPE ARE FOREIGN/ALIEN/TOXIC/POISONOUS.

Modern medicine has convinced us, for example, that the RISE IN ANTIBODIES from vaccines is a GOOD thing.  I'm going to say it isn't, and that it is demonstrating a response to a POISON, which is what all the rest of medical science says that the whole purpose of antibodies are.

What are autoantibodies then?

Definition of "autoantibody" from the National Cancer Institute

An antibody made against substances formed by a person’s own body. Autoantibodies can directly destroy cells that have the substances on them or can make it easier for other white blood cells to destroy them. Some autoimmune diseases are caused by autoantibodies.

What is causing the antibodies then?  Isn't that a good question?  Autoantibodies are a SYMPTOM of something deeper.

What is the relationship between antibodies and poisons/toxins?

Toxins Journal, Special Issue: Toxin-Antibody Interactions

Antibodies are remarkable in their ability to inactivate even the most potent plant and microbial toxins, including botulinum, tetanus, diphtheria, anthrax and ricin toxins.  While this fact has been recognized for more than a century, surprisingly little is known about the molecular mechanisms by which antibodies actually neutralize toxins.

Antibodies INACTIVATE POTENT PLANT TOXINS.  All Poison/"Vitamin A" originates in plant-based carotenoids, either we eat them directly, or the animals we eat have eaten them, and broken/degraded them down into retinoids.

Surprisingly little is known about how antibodies neutralize toxins?  Similar to modern medicine's suprisingly small knowledge about the cause of autoimmunity, a DISEASE THAT IS ASSOCIATED WITH ANTIBODIES?

This next quote is great.  If the body was toxic with Poison/"Vitamin A", what is its only effective defense?  Antibodies!

Monoclonal Antibodies and Toxins—A Perspective on Function and Isotype

Antibody therapy remains the only effective treatment for toxin-mediated diseases.

If carotenoids and thus retinoids are poisons/toxins, it would make sense that the body would increase antibody production to neutralize them, correct?

What if autoimmunity is the body's last-ditch effort to make an "effective treatment" of a poisoning?

If antibodies show up when toxic/poisonous/alien/foreign substances are introduced to the body, does Poison/"Vitamin A" increase antibodies?

Vitamin A and Retinoic Acid in the Regulation of B-Cell Development and Antibody Production

Vitamin A and RA [Retinoic Acid] regulate the maturation and differentiation of B cells at multiple levels that, in combination, regulate and often potentiate antibody production overall.
RA increased the proliferation of memory B cells
when B cells were stimulated with CpG DNA, which induces cell activation through TLR9 (Ertesvag et al., 2007). The increased rate of B-cell proliferation was accompanied by increased secretion of antibody.
RA promotes the expansion of a subset of B cells which undergo further differentiation (Chen and Ross, 2005), both processes leading to the promotion of antibody production.
Moreover, RA affects the FDC to increase
the efficiency of antigen presentation and antibody production (Suzuki et al., 2010). Furthermore, as discussed above, RA also regulates the expression of transcription factors that favor the differentiation of PCs and memory B cells (Chen and Ross, 2005). All these processes together may help to explain the enhanced antibody production by RA observed in animal studies in a T-cell dependent antigen immunization model (described below; Ma et al., 2005).
Previous studies have shown that RA and PIC cooperatively enhance the secondary antibody response, as well as the primary antibody response in both VA-deficient and VA-sufficient animals
(DeCicco et al., 20002001Ma and Ross, 2005Ma et al., 2005Ross et al., 2009).

There are more in that article.  I think the point has been made.  Vitamin A, particularly the most poisonous form of it as retinoic acid (modern medicine calls it the "most biologically active form", never forget that poisons are extremely "biologically active", just not in a good way!), increases antibody production across the board.

ANTIBODY SUMMARY:  The body makes antibodies to neutralize toxins/poisons.  Antibodies demonstrate the PRESENCE of toxic/poisonous/foreign/alien matter. Autoimmunity is a disease that is specifically associated with and diagnosed by the presence of antibodies.  Poison/"Vitamin A" increases antibody production.  

This next part is important.  If we were to believe that autoimmunity is not a confusion/failure of the immune system, but is rather the body "doing its best" in a poisoning situation, this next part will make more sense.  The last sentence is the most critical one.

Antibody treatment of toxin poisoning--recent advances.

The major responses to the administration of specific antibody or toxin-specific fragment are described. Toxin sequestration depends on the extent and rate of antibody distribution, the antibody affinity and its ability to form a non-active immune complex. Toxin redistribution is mainly influenced by the reversible binding and efflux kinetics of the toxin from the receptor. Finally, toxin elimination adopts the antibody elimination properties for low molecular weight compounds. These three basic mechanisms of the immuno-detoxification process could be optimized by designing the ideal antibody, in terms of size and origin, to inactivate the toxic properties.

Remember how I mentioned the "genetic weak link in the chain" theory above?  Note how autoimmune diseases are recognized by which tissue they "attack", and by the autoantibodies being present in the blood that are associated with that particular tissue being "attacked"?

Let's take a different look at it.  What if a tissue was being poisoned--and following in the vein of the last sentence above--the IDEAL ANTIBODY IN TERMS OF SIZE AND ORIGIN to the tissues being most POISONED, was DESIGNED BY THE BODY to optimally look a lot like the very tissue that was being destroyed?  Sort of like in the movies, when the good guys put on a disguise to look like the bad guys so they can infiltrate the enemy's defenses?

People will then say, "well, my autoimmunity can't be from Vitamin A, mine started after a vaccine/medication/surgery/etc."  See below.  The foundation of toxicity is established first, and then a STRESSOR is applied..."the straw that broke the camel's back."  Here's more on that:

Complement, natural antibodies, autoantibodies and tissue injury

Our experiments demonstrate that naturally occurring antibodies and autoantibodies mediate tissue injury only after an organ has been subjected to a stressor such as ischemia.

Poison/"Vitamin A" is the foundation.  This is sufficient by itself.

Glyphosate/Roundup.  Pharmaceuticals.  Vaccines.  Trauma.  These are the triggers that push over the threshold (whatever that is for each individual).

Where is the tipping point?  What is the trigger?  It's different for each person.

The good news is that the road to fixing is quite straightforward.

How does "Vitamin A deficiency" (not a real thing, but useful in this example) affect antibody production, particularly after a stressor like a vaccine is applied?

Prevnar-13 vaccine failure in a mouse model for vitamin A deficiency

In a mouse model for VAD [Vitamin A Deficiency], we found that PCV-13 failed to elicit binding and neutralizing antibody activities.

A FAILURE of antibody production?  There is a "lack" of Poison/"Vitamin A".  Remember from above, that Poison/"Vitamin A" has been studied as an adjuvant.  Less adjuvant present, no antibody reaction to vaccine.  With what you now know, less antibody production is a GOOD thing.

Does the presence of Poison/"Vitamin A" in combination with a vaccine increase antibody production?

Effect of Dietary Vitamin A on Reproductive Performance and Immune Response of Broiler Breeders

Supplementation of vitamin A at levels up to and including 35,000 IU/kg did not affect reproductive performance and quadratically affected antibody titer to Newcastle disease virus vaccine (p<0.05). 

Let me make sure we all understand what "quadratically affected antibody titer" means:

  • Poison/"Vitamin A" supplement = input X
  • Newcastle disease virus vaccine = input Y
  • Antibody production = output Z

[adding expert commentary on quadratic effect here]

Autoimmune reactions--aka antibody reactions to poisons--to vaccines are built upon a foundation of Poison/"Vitamin A" toxicity.  It's all right there.  Take away the Poison/"Vitamin A" foundation and the antibody reaction to vaccines (stressor/trigger) disappears.

As the epidemic of Poison/"Vitamin A" toxicity has increased, and the vaccine schedule has increased, we are now seeing massively increased negative reactions to vaccines (stressor).  It all goes together.  It's not just one thing, it never was, nor ever will be.  Everything has a foundation that it is built on.  Autoimmunity is built upon Poison/"Vitamin A" toxicity, and there are multiple ways to get there.

A quick note on Retinol-Binding Protein (RBP).  Note the words "binding protein", then look at the title of the next paper.

Toxin Neutralization Using Alternative Binding Proteins

So the body uses "binding proteins" to neutralize toxins?  Interesting.  Retinol-Binding Protein, as I have discussed before, is the first-line molecule your body makes to PROTECT YOU (especially your skin and your eyes) from the damaging effects of Poison/"Vitamin A".    Now the quote from the paper:

Toxins represent an extremely diverse field of targets, ranging from small molecules that exert their function via a binding interaction with a target macromolecule, to enzymes that exert their toxic function by catalyzing a reaction. 

The "toxin" known as Poison/"Vitamin A" ("small molecule") causes toxicity ("exert their function") through binding to the improperly-named RAR and RXR receptors that it is not intended or designed for ("target macromolecule").  This is the poisoning mechanism that has been so falsely interpreted.

Let's go through some of the examples.

This post covers how researchers were able to recreate a model of celiac disease in mice, however, it REQUIRED Poison/"Vitamin A" to be present to work.

Autoimmune hair loss:  Increased retinol-binding protein (RBP) 4 and anti-RBP4 antibody in alopecia areata.

CONCLUSIONS:  Our data demonstrate that AA [Alopecia Areata] is associated with increased serum levels of RBP4 and positive IgG immunoreactivity against recombinant human RBP4. These results suggest that the major components for the retinoic acid biosynthesis pathway may be crucially involved in the pathogenic process of AA.

RBP4 is Retinol-Binding Protein 4.  The body only makes RBP (of any type) when there is retinol around that it needs to protect itself from.  Therefore, an elevated RBP4 means that there is (or was) an elevated level of retinol around.  "Autoimmune" hair loss is therefore associated with Poison/"Vitamin A" toxicity.

Autoimmune eye disease was INDUCED in mice by injecting them with Retinol-Binding Protein 3 (RBP-3):

Experimental autoimmune uveoretinitis (EAU) in the C57BL/6J mouse is a model of non-infectious posterior segment intraocular inflammation that parallels clinical features of the human disease. The purpose of this study was to analyse the immune response to the four murine subunits of retinol binding protein-3 (RBP-3) to identify pathogenic epitopes to investigate the presence of intramolecular epitope spreading during the persistent inflammation phase observed in this model of EAU. Recombinant murine subunits of the RBP-3 protein were purified and used to immunize C57BL/6J mice to induce EAU.

Read that last sentence very carefully.  They "immunized" (vaccinated) the mice with Retinol-Binding Protein 3, in order to INDUCE AN AUTOIMMUNE DISEASE.  Do you get it yet?

Lupus in mice getting systemically worse via more Poison/"Vitamin A" retinoic acid (remember above, where I showed carrot juice increased ATRA, the same retinoic acid discussed below):

Paradoxical Effects of All-Trans-Retinoic Acid on Lupus-Like Disease in the MRL/lpr Mouse Model

After 8 weeks of tRA [all-trans Retinoic Acid, aka ATRA], but not VARA treatment,significantly higher pathological scores in the skin, brain and lung were observed. These were accompanied by a marked increase in B-cell responses that included autoantibody production and enhanced expression of plasma cell-promoting cytokines.

More Poison/"Vitamin A", more autoantibodies, more pathological damage!

Let's cover one more mechanism showing that Poison/"Vitamin A" increases the types of damage seen in autoimmune disease.  Citrullinated proteins in rheumatoid arthritis.  First, some background:

Rheumatoid arthritis and citrullination

Citrullinating enzymes (peptidylarginine deiminases, PADs) are tightly controlled to limit their hyperactivation. Calcium and redox conditions are important regulators of PAD activity. Studies suggest that citrullination is dysregulated both intra- and extracellularly in RA [Rheumatoid Arthritis]. In neutrophils, host (i.e. perforin and the membrane attack complex) and bacterial (i.e. toxins) pore-forming proteins induce prominent calcium influx, cytolysis and hyperactivation of PADs, which likely maintain hypercitrullination in the RA joint and at extra-articular sites of disease initiation, respectively. Autoantibodies that bind and activate PAD4 have also been identified in the circulation of patients with severe RA. Since the extracellular environment is oxidizing, conditions that are known to inactivate PADs, efficient extracellular citrullination in RA probably requires the constant release of active enzymes from dying cells and may be accelerated by PAD-activating autoantibodies. Understanding how PADs are hyperactivated in patients with RA and the array of citrullinated proteins generated (i.e. the citrullinome), is important to identifying pathways responsible for the development and maintenance of anti-citrullinated protein immune responses.

So PADs are hyperactivated in rheumatoid arthritis. Is there any evidence of Poison/"Vitamin A" increasing the activity of PADs?

Molecular Characterization of Peptidylarginine Deiminase in HL-60 Cells Induced by Retinoic Acid and 1α,25-Dihydroxyvitamin D3

We found that PAD activity in human myeloid leukemia HL-60 cells was induced with the granulocyte-inducing agents retinoic acid and dimethyl sulfoxide and with the monocyte-inducing agent 1α,25-dihydroxyvitamin D3.
Peptidylarginine deiminases (PADs)1 
(protein-arginine deiminase, protein L-arginine iminohydrolase, EC are a family of post-translational modification enzymes which convert arginine residues to citrulline residues in the presence of calcium ion. 

PAD activity was increased by Poison/"Vitamin A" retinoic acid, and also with Vitamin D3!

Calcium was mentioned in both papers above.  Note that hypervitaminosis A and hypervitaminosis D cause hypercalcemia.  More VA and/or more Vit D equals higher calcium levels floating around, and more VA and/or more Vit D around also increases PADs activity causing more citrullinated proteins associated with rheumatoid arthritis.

Some of my general advice is to fix people's chronic Vitamin A toxicity and to nearly always avoid Vitamin D supplements!  Funny how the research on autoimmunity backs those things up nicely here.

In summary:

Dr. Garrett Smith, the "Nutrition Detective"
Licensed Naturopathic Physician (NMD) in Arizona
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