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*work in progress* Connecting Poison/"Vitamin A", Vitamin D, and Zinc

Resistant starch: implications in kidney health and vitamin D homeostasis in diabetes mellitus

https://lib.dr.iastate.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=5823&context=etd
"Molecular Action of Vitamin D
The actions of 1,25D are mediated by the membrane-bound vitamin D receptor (VDR), a nuclear receptor that belongs to a subclass of nuclear transcription factors. Upon the binding of 1,25D, VDR translocates from the cytosol to the nucleus where it is phosphorylated and forms a heterodimer with the retinoid X receptor (RXR). The VDR-RXR heterodimer complex can then binds to vitamin D response elements (VDRE) and induce transcription of genes [146, 148]. There are two major functional units of the human VDR, the N-terminal zinc finger DNA-binding domain and the C-terminal ligand-binding domain. Gene expression mediated by 1,25D and VDR is initiated by the RXR heterodimerization. The presence of liganded VDR changes the position of H12 at the C-terminus of VDR for coactivator binding, which further promotes histone acetylation and chromatin remodeling [146]. Transcriptional regulation by 1,25D-bound VDR involves a number of steps at the level of the gene."

That's a mouthful.  It would seem to make sense that Poison/"Vitamin A" toxicity, zinc deficiency (which is nearly everywhere and impacts Vitamin D metabolism as well as Retinol Binding Protein needed to prevent Poison/"Vitamin A" toxicity), and the supposed "Vitamin D deficiency epidemic" (Vit. D is a hormone and should not be "eaten" in supplement form--including cod liver oil--ever, it ends in disaster) are now all tied together and impact the body all the way down to the DNA level.

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Dr. Garrett Smith, the "Nutrition Detective"
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