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Rhabdomyolysis is increasing, and can be linked to Poison/"Vitamin A"

Rhabdomyolysis (aka "rhabdo") is a serious syndrome due to a direct or indirect muscle injury, resulting in the death of muscle fibers and the release of their contents into the bloodstream. This can lead to serious complications such as renal (kidney) failure.  Not a good thing.

Are rhabdo visits to emergency rooms increasing?  You bet!

Rhabdomyolysis: Patterns, Circumstances, and Outcomes of Patients Presenting to the Emergency Department

From a total of 1,957 rhabdomyolysis cases, 89 patients (70.8% male) were identified as having exertional rhabdomyolysis. The frequency of presentation increased from 0.28/10,000 presentations in 2005 to 3.5/10,000 in 2015 [a 10x plus increase]. Gym-induced exertional rhabdomyolysis was the primary subcategory (53.9%) for these cases, and manual labor was the second most common subcategory (15.7%).

So are there any forms of Poison/"Vitamin A" associated with greatly increasing the risk of rhabdo?  You bet!  Isotretinoin is 13-cis-retinoic acid, also known as Accutane.

Severe rhabdomyolysis with isotretinoin therapy for acne

Severe generalised rhabdomyolysis with fatal outcome associated with isotretinoin.

Muscle damage induced by isotretinoin

[Rhabdomyolysis after isotretinoin treatment in a 17-year-old male].

Rhabdomyolysis induced by Isotretinoin

Isotretinoin induced rhabdomyolysis? A case report.

Exercise‐Induced Rhabdomyolysis Associated with Isotretinoin Therapy: A Case Report

Fatal rhabdomyolysis after acne therapy

There seems to be enough to entertain the possibility, no?

I find it interesting that researchers found it suitable to study the amount of retinol-binding protein as a marker of kidney injury, when the main damage done by rhabdo is to the kidneys:

Assessment of urinary retinol-binding protein as an index of proximal tubular injury.

The urinary excretion of retinol-binding protein (RBP), beta 2-microglobulin (beta 2-m), and beta-N-acetyl-D-glucosaminidase was monitored in patients with renal tubular damage secondary to multiple injuries, rhabdomyolysis, antibiotic treatment, or poisoning by various chemicals such as solvents, heavy metals, or pesticides. In almost all cases, RBP proved to be a more sensitive index of renal tubular damage than was beta-N-acetyl-D-glucosaminidase and, being more stable in acid urine, a more practical analyte to measure than was beta 2-m.
[...]
Under these conditions the determination of RBP protein in urine appears the most appropriate test when early detection of tubular injury is desirable.

Retinol-binding protein, as I have discussed elsewhere, is designed and intended to protect the body from Poison/"Vitamin A".  Kidney damage has long been associated with Poison/"Vitamin A". Seems logical enough that RBP would be around in the aftermath to me.

Dr. Garrett Smith, the "Nutrition Detective"
Licensed Naturopathic Physician (NMD) in Arizona
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