Quote from Dr. Garrett Smith on November 15, 2018, 11:33 am

This post will take a while to complete, so I'm putting the evidence here as I find it.

From a FB post of mine about this:
New theory. I already believe that what people think of as "methylation" problems are simply manifestations of Poison/"Vitamin A" toxicity. I'm assembling a whole list of things on the blog-forum that help with either detoxing or protecting the body from Poison/"Vitamin A". Some of these match the compounds that are recommended for undermethylators or overmethylators, and the opposite is also true, that some of these compounds shouldn't be taken by a certain type of methylator status.

The theory then is...using a person's methylation presentation of labs and symptoms, "extra credit" foods and/or supplements could be specifically recommended that would help that person to have an easier time passing through these detox months (3-6 months is the length of the detox when done properly).

Example. Choline is a part of lecithin (phosphatidylCHOLINE). Lecithin is part of the enzyme lecithin retinol acyltransferase (LRAT). This enzyme seems to help turn the "free" damaging forms of Poison/"Vitamin A" back into safer "storage" forms...and it may help to reduce toxicity/detox symptoms by doing just that. Understand that many of the toxicity/detox symptoms are likely arising from too many of the "free" forms floating around at one time. Choline deficiency is associated with anxiety (google it if you wish), a major Poison/"Vitamin A" toxicity/detox symptom, so there is that plausible connection.

Choline is recommended for the overmethylator type, and not for the undermethylator type. I'm an undermethylator type, and I can tell you that supplementing lecithin in the past has NEVER done anything I could feel. I now have several overmethylator types (they're more rare, only about 10-15% of the population) who have reported benefit from taking lecithin, and this was before I started the Poison/"Vitamin A" detox approach. So, the connection seems to be building.

Please don't ask me below if YOU should take lecithin, I don't give recommendations here. If you decide to take it on your own and you are not sure of your methylator status (it's quite a bit more difficult to assess in many cases than the interwebz intellectual-yet-idiot no-skin-in-the-game non-practitioner bloggers would have you believe), then you taking it is a guessing game. That's on you.

Is this necessary? No, the detox alone does the MAIN work. Might this make the whole process easier to go through? Yes. Might this also help heal some of the damage/issues caused by the poisoning sooner? Yes, that makes sense. Is this going to make it so you can eat as much Poison/"Vitamin A" as you want? I think you missed the point.

--

Inositol is used with undermethylators, and often helps with the overactive brain (read: anxiety) at night that keeps people from falling asleep. It seems that Poison/"Vitamin A" decreases inositol uptake: https://www.ncbi.nlm.nih.gov/pubmed/2538335
"In conclusion, RA treatment of 3T3 fibroblasts decreases the uptake of [3H]inositol by up to 70% within 8 to 10 h at near physiological concentrations in a reversible and specific manner."