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Glyphosate induces both UNDERmethylation and OVERmethylation

If you are thinking that your genetics have doomed you to a life of forever "treating" your supposed "methylation defects", yet past generations of your family didn't seem to manifest all of these problems, I'm here to suggest that it is the addition of glyphosate/Roundup to the environment over the last 40 years that is the main cause of all your methylation problems, and Poison/"Vitamin A" toxicity only worsens the problem.

An example of how glyphosate can confusingly cause both undermethylation and overmethylation, aka hypermethylation and hypomethylation, is shown in this study:

DNA damage and methylation induced by glyphosate in human peripheral blood mononuclear cells (in vitro study).

Glyphosate is a very important herbicide that is widely used in the agriculture, and thus the exposure of humans to this substance and its metabolites has been noted. The purpose of this study was to assess DNA damage (determination of single and double strand-breaks by the comet assay) as well as to evaluate DNA methylation (global DNA methylation and methylation of p16 (CDKN2A) and p53 (TP53) promoter regions) in human peripheral blood mononuclear cells (PBMCs) exposed to glyphosate. PBMCs were incubated with the compound studied at concentrations ranging from 0.1 to 10 mM for 24 h. The study has shown that glyphosate induced DNA lesions, which were effectively repaired. However, PBMCs were unable to repair completely DNA damage induced by glyphosate. We also observed a decrease in global DNA methylation level at 0.25 mM of glyphosate. Glyphosate at 0.25 mM and 0.5 mM increased p53 promoter methylation, while it did not induce statistically significant changes in methylation of p16 promoter. To sum up, we have shown for the first time that glyphosate (at high concentrations from 0.5 to 10 mM) may induce DNA damage in leucocytes such as PBMCs and cause DNA methylation in human cells.

Decreasing AND increasing methylation in different areas?  Do you start to see why almost no one out there seems to have a really good handle on this methylation issue?  Different people are affected in different ways by the same poison.  Humanity didn't all of a sudden have a giant genetic shift in methylation problems...what it did have was an insidious infection of their environment by glyphosate and Poison/"Vitamin A".  In other posts I'll show how Poison/"Vitamin A" ALSO affects methylation in "confusing" ways.

Dr. Garrett Smith, the "Nutrition Detective"
Licensed Naturopathic Physician (NMD) in Arizona
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