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Case Study: Severe hypervitaminosis A in siblings: Evidence of variable tolerance to retinol intake

Different people within the same family will have different tolerances to Poison/"Vitamin A" and will show toxicity in different timeframes.  Men and women have different tolerances as well.

Severe hypervitaminosis A in siblings: Evidence of variable tolerance to retinol intake

A 2-year-old boy had signs and symptoms of chronic hypervitaminosis A. A course of increasing severity led to eventual death.

This is what I refer to as the Poison/"Vitamin A" toxicity "Double Down Mistake".  Someone gets sick FROM TOO MUCH Poison/"Vitamin A", and then makes the MISTAKE (deadly in this case) of taking even MORE Poison/"Vitamin A" in the hopes of fixing the problems.  This is the epitome of the "definition of insanity".  There are minor internet nutrition celebrities out there making this same mistake right now.

"Doubling down" means to strengthen one's commitment to a particular strategy or course of action, typically one that is potentially risky.

A younger brother later had similar clinical features. Chicken liver spread containing up to 420 IU/g vitamin A was the likely source of intoxication. Markedly elevated circulating retinyl ester levels have persisted in the surviving sibling for 3 subsequent years despite severe restriction of vitamin A intake.

3 YEARS LATER "despite severe restriction of vitamin A intake".  Let that really sink into your brain.  Do you see why I continually say that Poison/"Vitamin A" must be purposefully avoided, depleted, and detoxed to get rid of the problem?  It's not just "stopping Vitamin A supplements" or "stopping eating liver" or "stopping taking cod liver oil".  MORE must be done.  Hence, my Poison/"Vitamin A" Detox Program.

A therapeutic trial of the carbohydrate-derived complexing agent 2-hydroxypropyl-β-cyclodextrin was initiated. Circulating retinyl esters transiently increased during the infusion (from 407 to 4791 μg/dL), and urinary total vitamin A excretion, undetectable before infusion, increased to 23 μg/dL after infusion. The frequency of hypervitaminotic episodes has decreased somewhat in the 2 years since the infusion, probably related to dietary vitamin A restriction. The occurrence of this syndrome in two brothers, while a sister ingesting the same diet remains completely healthy, suggests an inherited variance in tolerance to vitamin A intake.

The idea that one infusion would fix the problem entirely is laughable to me.  Sure, it helped.  No, it had no chance of permanently fixing the issue.

Note how the older sister never had problems, one brother died (the youngest, with the smallest liver capacity to absorb the poison), and one brother still had problems YEARS LATER.

Dr. Garrett Smith, the "Nutrition Detective"
Licensed Naturopathic Physician (NMD) in Arizona, home of the Love Your Liver program
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