Quote from Dr. Garrett Smith on November 14, 2018, 12:51 pm

This one is weak in terms of research to support a connection, but an absence of evidence does not imply evidence of absence.  What does glucaric acid do in the body?

[The biological role of D-glucaric acid and its derivatives: potential use in medicine].

https://www.ncbi.nlm.nih.gov/pubmed/18772850
"D-glucaric acid is a natural non-toxic compound produced in small amounts by mammals, including humans. In mammals, D-glucaric acid and D-glucaro-l,4-lactone are end-products of the D-glucuronic acid pathway. The enzyme D-glucuronolactone dehydrogenase has been found to be responsible for the oxidation of the lactone of D-glucuronic acid to D-glucaro-l,4;6,3-dilactone. This dilactone hydrolyzes spontaneously in aqueous solution to D-glucaro-l,4-lactone, a potent beta-glucuronidase inhibitor. D-glucaric acid is also found in many fruits and vegetables, with the highest concentrations found in grapefruits, apples, oranges, and cruciferous vegetables. b-glucuronidase is present in the circulation and probably all vertebrate tissues and is capable of hydrolyzing glucuronide conjugates. This enzyme is also produced by colonic microflora. Elevated b-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast and prostate cancer. D-glucaro-l,4-lactone increases detoxification of carcinogens and tumor promoters by inhibiting b-glucuronidase and preventing the hydrolysis of their glucuronides. D-glucaro-l,4-lactone was found to be formed from supplemented D-glucarate salt in the stomach and it is absorbed from the intestinal track, transported with the blood to different internal organs, and excreted in urine and, to a lesser extent, in bile. D-glucaro-l,4-lactone and its precursors exert their anticancer action in part through alterations in steroidogenesis accompanied by changes in the hormonal environment and proliferative status of the target organs. D-glucarates not only suppress cell proliferation and inflammation, but also induce apoptosis. By supplementing D-glucarates, one can favor the body's natural defense mechanism for eliminating carcinogens and tumor promoters and their effects."

Sounds like a good thing, right?  There are several papers on glucarate/glucaric acid used in combination with Poison/"Vitamin A"...

Basis for the anti-tumor and chemopreventive activities of glucarate and the glucarate:retinoid combination.

https://www.ncbi.nlm.nih.gov/pubmed/8517653
"The biochemical basis for the cancer chemopreventive and anti-cancer activities of glucarate, retinoids (13-cis-retinoic acid, hydroxyphenyl retinamide) and their synergistic combination, has been evaluated. Neither alone nor in combination did these agents affect the level in the rat, of enzymes which are (a) known to correlate with reduced risk of carcinogenesis (detoxification enzyme, catalase, glutathione reductase) nor (b) enzymes which correlate with increased risk of carcinogenesis (beta-glucuronidase, xanthine oxidase, glucose-6-phosphate dehydrogenase). Retinoids, but neither glucarate nor its lactone inhibited free radical-induced lipid peroxidation. Both agents alone and synergistically in combination, raise cellular cAMP levels, repress protein kinase C and more generally inhibited DNA synthesis."

Activity of D-glucarate analogues: synergistic antiproliferative effects with retinoid in cultured human mammary tumor cells appear to specifically require the D-glucarate structure.

https://www.ncbi.nlm.nih.gov/pubmed/8190001
"D-Glucarate has shown modest chemopreventive and synergistic chemopreventive effects with retinoids in a number of tumor models as well as a similar antiproliferative effect in MCF-7 human tumor cells in culture. It has been postulated that D-glucarate exerts some of its effects by equilibrium conversion to D-glucarolactone, a potent beta-glucuronidase inhibitor. In the present study, D-glucarate and a number of its analogues, including D-glucarolactone, were evaluated as antiproliferatives in the MCF-7 model with and without added retinoid. Results suggest that the effects of glucarate are reasonably specific for its structure and may not require conversion to glucarolactone."

Pharmacokinetics relevant to the anti-carcinogenic and anti-tumor activities of glucarate and the synergistic combination of glucarate:retinoid in the rat.

https://www.ncbi.nlm.nih.gov/pubmed/8185680
"Alone and in synergistic combination with retinoids, dietary glucarate inhibits both the chemical induction and growth of rat mammary tumors. To investigate the pharmacokinetics of glucarate, [14C]glucarate was synthesized, converted to the calcium salt, and administered to rats bearing primary mammary tumors. When given by gavage, [14C]glucarate, as the calcium salt, showed a biphasic response in the blood. After peaking within 1 hr of administration at a level of 0.4 mumol/mL (normal endogenous level is approximately 0.04 mumol/mL), its plasma concentration dropped to 0.1 mumol/mL at 3 hr. In the second phase, there was a semilog increase to 0.6 mumol/mL at 15 hr, followed by a slow rise to 0.75 mumol/mL at 24 hr. Of the 38% of the administered glucarate that was recovered, 38% was excreted in the urine, and 30% remained in the gastrointestinal tract at 24 hr. Glucarate was concentrated 3- to 4-fold in the liver and intestinal mucosa, compared to the level in serum. With minor exception, the pharmacokinetics of [14C]13-cis-retinoic acid administered by gavage to rats was similar or not the semipurified diets were supplemented with 64 mmol/kg of calcium glucarate. During the interval between 5 and 10 hr post-administration of [14C]13-cis-retinoid, there was a transient 35-50% rise in the plasma level in rats on the glucarate-supplemented diet. This rise had no observable effect on the level of retinoid in major organs or in the tumor. A glucarate-binding protein was detected in the tumor cytosol. This potential receptor had a Ka of 1.49 x 10(7) M-1."

I would theorize that the rise in plasma level of Poison/"Vitamin A" due to glucarate supplementation in that last paper is related to some sort of detoxification process ramping up.  Reading Grant Genereux's third e-book (linked here on another thread and at ggenereux.blog/ ) on the connection between Poison/"Vitamin A" and breast cancer would be relevant here for those interested in more specific information on that topic.

Fruit and vegetable glucarate/glucaric acid contents (also attached):

d -Glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary d -glucarate in the rat

https://kundoc.com/pdf-d-glucaric-acid-content-of-various-fruits-and-vegetables-and-cholesterol-lowerin.html

Note in that paper it is mentioned that glucarate/glucaric acid lowers cholesterol...and one of the ways the body detoxes Poison/"Vitamin A" (through biotransformation) is by turning some of it into cholesterol.  Could Chronic Insidious Vitamin A Toxicity be the root cause of the symptom called "high cholesterol"?  I believe it absolutely could, and there are other mechanistic connections that will be presented linking that in this blog-forum.

Foods that are high in glucarate/glucaric acid AND low in Poison/"Vitamin A" include (with any green foods on this list, the lighter the green color, the less Poison/"Vitamin A" content):

• ALL should be organic, see the glyphosate/Roundup and organochlorine pesticide threads for more info
• Cauliflower
• Mung beans (and sprouts)
• Iceberg/crisphead lettuce
• Green cabbage
• Celery
• Adzuki/azuki beans (and sprouts)
• Grapes (white or red), so this includes raisins/sultanas, grape juice, and wine
• Pear
• Lemon
• Cherries (their red color is not from carotenoids, it is from cyanidins)
• Apples

These are only the foods that are both high in glucarate/glucaric acid AND low in Poison/"Vitamin A". Many more foods are listed in my Poison/"Vitamin A" Detox folder online.  Contact us for pricing and access.