Quote from Dr. Garrett Smith on November 13, 2018, 8:42 pm

Just a quick one for those who are trying to avoid heart disease.

Expression and activation of the farnesoid X receptor in the vasculature

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367262/
"FXR/RXR Agonists Induce Vascular Smooth Muscle Cell Death by Apoptosis. 

The RXR ligand 9-cis retinoic acid (9cRA), up to 30 μM, induced RASMC [Rat Aorta Smooth Muscle Cell] death in a concentration-dependent manner (Fig. 3A)"

More Vitamin A, more cell death.  Here is where your aorta is: