Quote from Dr. Garrett Smith on November 17, 2018, 1:27 pm

I'm just putting things here to keep them for later.

Compounds that "potentiate", "restore sensitivity", "induce", "sensitize"--among other related terms--retinoic acid (aka Poison/"Vitamin A") that are found in the research to be highly associated with health and longevity, are quite possibly doing so because of their effect on Poison/"Vitamin A" metabolism in a good way (ie. either protecting against its damage or helping to detoxify it).  There is something to this.  Several examples below.

Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells

https://link.springer.com/article/10.1007%2Fs12185-010-0627-4
Note "potentiates".  Ellagic acid is found in things like pomegranates and green tea, both found to be very healthy in the literature in general.  At the time of writing, 52 more papers on ellagic acid here: http://www.greenmedinfo.com/substance/ellagic-acid

Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192446/
Note "restores sensitivity".  Turmeric/curcumin has been found to be somewhat helpful for nearly all health conditions.
2600+ papers on turmeric here: http://www.greenmedinfo.com/substance/turmeric
2400+ papers on curcumin here: http://www.greenmedinfo.com/substance/curcumin

See Grant Genereux's third e-book on cancer for many connections between Poison/"Vitamin A" toxicity and breast cancer.  If you don't want to read that whole book, there is this paper (you must first know that Retinol Binding Proteins are used as stand-in/surrogate measures of serum Vitamin A/retinol, so if they are elevated, that directly implies that serum Vitamin A/retinol is ALSO elevated):

Elevated Serum Levels of Retinol-Binding Protein 4 Are Associated with Breast Cancer Risk: A Case-Control Study

https://www.ncbi.nlm.nih.gov/pubmed/24483971
"Results
The serum levels of RBP4 were significantly higher in patients with breast cancer than that in the healthy control group"

Something is going on here with things that are said to "potentiate" retinoic acid, particularly in cancer research, and these compounds we're talking about have shown many real-world benefits overall.  I think the process was misinterpreted by the researchers, who are biased towards looking at Poison/"Vitamin A" in a good way.  We may not always know the exact mechanism.  We first look at the Black Box results, then if we are able, and if the science is there, we can try to work backwards towards a mechanism.

If the compounds were somehow kicking out the retinoic acid, reducing its negative impacts on the cell, then this might be observed from the outside INCORRECTLY as the compound "potentiating" or "sensitizing" the cells to retinoic acid once again.  It's all in how the researchers wanted to interpret what they were seeing.  Why would the cells have become "resistant" to retinoic acid in the first place?  Maybe because they were already FULL of it?  Just theorizing.