Research Forum
Obesity as a defense against Poison/"Vitamin A" toxicity
Quote from Dr. Garrett Smith on November 21, 2018, 12:33 pmIf you haven't read Grant Genereux's blog post on the significant correlation between obesity and blood levels of Vitamin A, you should: https://ggenereux.blog/2018/10/08/obesity-causation/
Then, there is this:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629132/
"Thus, obesity causes a “silent” VA [Poison/"Vitamin A"] deficiency marked by reductions in VA levels and signaling in multiple organs, but not detected by serum VA."Because I truly believe in the wisdom of the body, and the body does the best it can with the situations it is put in, I believe that the creation of excess bodyfat is one method the body uses as a DEFENSE against Poison/"Vitamin A" toxicity. Fat-soluble toxins can then be "diluted" more, and are then "less toxic per unit of bodyfat".
Apparently two of the major tissues that make Retinol Binding Protein (your main defense against Poison/"Vitamin A") are the liver and the BODYFAT...so if the liver can't handle the job by itself any longer, then the body starts making more bodyfat.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(07)00158-1
"Levels of serum retinol-binding protein (RBP4), secreted by fat and liver cells, are increased in obesity and type 2 diabetes (T2D)."
Remember that when RBP levels are higher, that is a surrogate/indirect way of saying that Poison/"Vitamin A" levels are higher.In an amazing coincidence, FATTY LIVER is also associated with Poison/"Vitamin A" toxicity. Even the poor liver starts creating more fat as a further defense mechanism.
If you haven't read Grant Genereux's blog post on the significant correlation between obesity and blood levels of Vitamin A, you should: https://ggenereux.blog/2018/10/08/obesity-causation/
Then, there is this:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629132/
"Thus, obesity causes a “silent” VA [Poison/"Vitamin A"] deficiency marked by reductions in VA levels and signaling in multiple organs, but not detected by serum VA."
Because I truly believe in the wisdom of the body, and the body does the best it can with the situations it is put in, I believe that the creation of excess bodyfat is one method the body uses as a DEFENSE against Poison/"Vitamin A" toxicity. Fat-soluble toxins can then be "diluted" more, and are then "less toxic per unit of bodyfat".
Apparently two of the major tissues that make Retinol Binding Protein (your main defense against Poison/"Vitamin A") are the liver and the BODYFAT...so if the liver can't handle the job by itself any longer, then the body starts making more bodyfat.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(07)00158-1
"Levels of serum retinol-binding protein (RBP4), secreted by fat and liver cells, are increased in obesity and type 2 diabetes (T2D)."
Remember that when RBP levels are higher, that is a surrogate/indirect way of saying that Poison/"Vitamin A" levels are higher.
In an amazing coincidence, FATTY LIVER is also associated with Poison/"Vitamin A" toxicity. Even the poor liver starts creating more fat as a further defense mechanism.
Licensed Naturopathic Physician (NMD) in Arizona
NutritionDetective.com, home of the Love Your Liver program
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