Poison/"Vitamin A" is estrogenic via increasing aromatase activity, which is what turns testosterone into estrogen. This also makes it anti-testosterone ("defined in literature" below, even!). Here is the real-world evidence:
Gynecomastia: a rare complication of isoretinoin?
Isotretinoin is a retinoic acid derivative mostly used in the treatment of cystic acne vulgaris. The adverse effects of isotretinoin are well defined being the major limitation factor for its usage. The decrement of testosterone during isoretinoin treatment is defined in literature. We present a case with 20 years old man who developed gynecomastia after treatment with isotretinoin. To the best of our knowledge, this is the third report of the development of gynecomastia after isotretinoin treatment.
Poison/"Vitamin A" is estrogenic via increasing aromatase activity, which is what turns testosterone into estrogen. This also makes it anti-testosterone ("defined in literature" below, even!). Here is the real-world evidence:
Gynecomastia: a rare complication of isoretinoin?
Isotretinoin is a retinoic acid derivative mostly used in the treatment of cystic acne vulgaris. The adverse effects of isotretinoin are well defined being the major limitation factor for its usage. The decrement of testosterone during isoretinoin treatment is defined in literature. We present a case with 20 years old man who developed gynecomastia after treatment with isotretinoin. To the best of our knowledge, this is the third report of the development of gynecomastia after isotretinoin treatment.
